Deutsche Bank analyst Amit Mehrotra sees potential for 75% additional upside in shares of XPO Logistics. The biggest theme in U.S. transportation is the ongoing restructuring of America's retail landscape, Mehrotra tells investors in a research note.

E-commerce is accelerating, while most traditional brick-and-mortar outlets are in stagnation, the analyst contends. He estimates e-commerce penetration will increase 50% by 2020 relative 2016, equating to 75% growth in e-commerce sales, should current trends continue.

XPO is one of the biggest beneficiaries of these secular trends, Mehrotra writes. He has a Buy rating on XPO with a $75 price target. The provider of supply chain solutions closed Friday up 60c to $54.45.